Method of Collection:
Volume as mentioned on gel vacutainer (Yellow)
Days for reporting:
|INTERPRETATION OF RATIOS
POSITIVE : MORE THEN 55.00 IU/ml
EQUIVOCAL : 35.00 - 55.00 IU/ml
NEGATIVE : LESS THEN 35.00 IU/ml
Why is the Test Done?
The anti-double stranded DNA (anti-dsDNA) test is used to help diagnose lupus (systemic lupus erythematosus, SLE) in a person who has a positive result on a test for antinuclear antibody (ANA) and has clinical signs and symptoms that suggest lupus. Anti-dsDNA is one of a group of autoantibodies called antinuclear antibodies that are produced by a person's immune system when it fails to distinguish between "self" and "nonself." ANA target substances found in the nucleus of cells. Anti-dsDNA specifically target the genetic material (DNA) found in the nucleus, causing organ and tissue damage The anti-dsDNA test is fairly specific for lupus; however, only 50-70% of people with lupus may be positive; that is, a negative anti-dsDNA does not rule out lupus. If a person has a positive ANA, an anti-dsDNA test may be used to distinguish lupus from other autoimmune disorders that have similar signs and symptoms. The anti-dsDNA test may be used to monitor the severity of the disease in a person who has been diagnosed with lupus. Those with lupus often have flare-ups in which symptoms worsen and then subside. An increased anti-dsDNA level may be seen prior to and during these flare-ups. In particular, this test may be used to monitor lupus nephritis, a serious complication of lupus that can cause kidney damage and inflammation. This can lead to protein in the urine, high blood pressure, and kidney failure. It occurs when the autoantibodies bind to antigens and become deposited in the kidneys.
How to prepare for the Test:
No test preparation is needed